miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1
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چکیده
منابع مشابه
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1.
Using RNA-seq technology, we found that the majority of microRNAs (miRNAs) present in CFU-E erythroid progenitors are down-regulated during terminal erythroid differentiation. Of the developmentally down-regulated miRNAs, ectopic overexpression of miR-191 blocks erythroid enucleation but has minor effects on proliferation and differentiation. We identified two erythroid-enriched and development...
متن کاملRESEARCH COMMUNICATION miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Computation and Systems Biology, Singapore-Massachusetts Institute of Technology Alliance, Singapore 117576; Stem Cell and Developmental Biology, Genome Institute of Singapore, A*STAR, Singapore 138627; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA; Department of Bi...
متن کاملErythroblast Enucleation
Even though the production of orthochromatic erythroblasts can be scaled up to fulfill clinical requirements, enucleation remains one of the critical rate-limiting steps in the production of transfusable red blood cells. Mammalian erythrocytes extrude their nucleus prior to entering circulation, likely to impart flexibility and improve the ability to traverse through capillaries that are half t...
متن کاملSignaling and cytoskeletal requirements in erythroblast enucleation.
To understand the role of cytoskeleton and membrane signaling molecules in erythroblast enucleation, we developed a novel analysis protocol of multiparameter high-speed cell imaging in flow. This protocol enabled us to observe F-actin and phosphorylated myosin regulatory light chain (pMRLC) assembled into a contractile actomyosin ring (CAR) between nascent reticulocyte and nucleus, in a populat...
متن کاملmiR-191 Modulates Malignant Transformation of Endometriosis Through Regulating TIMP3
BACKGROUND Although aberrant expression of several miRNAs was found during the pathological development of endometriosis to endometriosis-associated ovarian cancer (EAOC), their roles are not fully understood. miR-191 is a miRNA significantly upregulated in endometriosis and EAOC patients. However, its downstream network is still not clear. This study explored its role in malignant transformati...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2010
ISSN: 0890-9369
DOI: 10.1101/gad.1998711